Effectiveness & Testimonials
Cryoablation has shown promising results in treating early-stage, hormone-sensitive breast cancers. The procedure involves using extreme cold to freeze and destroy cancerous tissues, offering a less invasive alternative to traditional surgeries like lumpectomy or mastectomy.
Cryoablation Improves Patient Satisfaction
Effective & Safe
Cancer control equal to lumpectomy for early stage breast cancer
Physical Well-being
Less pain or tightness and less difficulty with mobility, such as lifting arms.
Sexual Well-being
Greater feelings of sexual attractiveness, sexual confidence, and comfort level during sex
Satisfaction with Breasts
Greater happiness about breast size, how bras fit, and appearance in the mirror clothed or unclothed, as well as how the breasts feel to the touch.
Clinical Effectiveness of Cryoablation
Studies have highlighted the following key findings:
- Efficacy for Small Tumors: Cryoablation is most effective for tumors 2 cm or smaller. The American College of Surgeons Oncology Group (ACOSOG) Z1072 trial reported a 100% success rate for tumors less than 1 cm and a 92% success rate for tumors up to 2 cm.
- Long-Term Success: A Japanese clinical trial involving 304 women with stage I invasive ductal carcinomas reported a 0.98% local recurrence rate over six years, demonstrating the long-term effectiveness of cryoablation when combined with anti-estrogen medications and radiation therapy.
- In April 2024, the 5-year follow-up results of the ICE3 trial were presented at the annual meeting of the American Society of Breast Surgeons in Orlando, Florida. The ICE3 trial is multicenter, single-arm, non-randomized clinical trial that evaluated the role of cryoablation as an alternative to surgery. The trial enrolled 194 women years of age (median 75 years) with unifocal, clinical stage I, histologic grade 1 or 2, estrogen receptor positive, progesterone receptor positive, HER2/neu negative invasive ductal carcinoma diagnosed by minimally invasive biopsy. The use of anti-estrogen therapy, radiation therapy, and sentinel node biopsy were not mandated by the trial. As such, nearly 80% of ICE3 trial participants utilized endocrine therapy but only 14% received adjuvant radiation therapy and only 8% of participants underwent a sentinel node biopsy. At 5 years of follow-up, there were 7 recurrences of cancer in the same breast yielding a local recurrence free survival rate of 96.7%, which is comparable to lumpectomy clinical trials in women over 60 years of age where radiation therapy was omitted. The 5-year results will be published soon.
Cryoablation also offers theoretical benefits in stimulating an anti-cancer immune response, although this effect is not yet fully proven in humans. Proteins released from cryoablated tumors may help the immune system recognize and attack remaining cancer cells, potentially providing additional protection against recurrence.
Quick, Minimally Invasive, and Highly Effective.
Effectiveness in killing targeted cancer cells.
Average duration of the cryoablation procedure.
Typical recovery time before resuming normal activites.
Local recurrence rate in patients over a 6-year folow-up.
Real Stories from Dr. Holmes’ Patients
Courteous staff, excellent doctor. He took his time with me, which I greatly appreciate.
Martha H.
Patient
Nice doctor, nice staff, Dr. Holmes spent a lot of time speaking with me regarding my upcoming procedure he wasn’t rushing with the appointment like a lot of doctors do he listened to my questions and concerns very happy with meeting with him
Toni M.
Patient
Very Caring physician made me feel SAFE
Clara C.
Patient
Dr Holmes is one of the most thorough, knowledgeable, professional and caring doctors I've ever met. From the beginning I felt I was in good hands with him. And now a year and a half after my surgery, I'm doing well. But I am able to contact his staff at any time for questions or concerns. He works extremely well with my oncologist, my integrative oncologist, the radiologist and my general doctor. I live in a different state but was able to travel to California for surgery. Dr Holmes is extremely caring and he goes above and beyond! I would recommend him to any woman who has breast cancer. He is the best of the best!
Vicki G.
Patient
Dr. Holmes and his staff treated me very well thru a difficult time in my life after my diagnosis. I'm very grateful for the surgery he performed. He is a an excellent dr and was very kind and compassionate for my situation.
Laurice K.
Patient
Well explained and take cared
Mary Ann F.
Patient
Dr. homes and staff were very helpful and careing, specific Alba, she is amazing with patient and undrestanding.
Siman B.
Patient
Thank you for your hard work and dedication, and for giving women options. I so very much appreciate all you have done for me. I can share my story with others. God blessings to all.
L V B.
Patient
My mom and I want to thank you and your staff for giving us another option to mastectomy and taking such good care of me before, during and after the cryoablation. I am grateful beyond words to be a part of this trail-blazing effort to challenge the boundaries of conventional breast cancer treatments.
A E.
Patient
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