Effectiveness & Testimonials
Cryoablation has shown promising results in treating early-stage, hormone-sensitive breast cancers. The procedure involves using extreme cold to freeze and destroy cancerous tissues, offering a less invasive alternative to traditional surgeries like lumpectomy or mastectomy.
Cryoablation Improves Patient Satisfaction
Effective & Safe
Cancer control equal to lumpectomy for early stage breast cancer
Physical Well-being
Less pain or tightness and less difficulty with mobility, such as lifting arms.
Sexual Well-being
Greater feelings of sexual attractiveness, sexual confidence, and comfort level during sex
Satisfaction with Breasts
Greater happiness about breast size, how bras fit, and appearance in the mirror clothed or unclothed, as well as how the breasts feel to the touch.
Clinical Effectiveness of Cryoablation
Studies have highlighted the following key findings:
- Efficacy for Small Tumors: Cryoablation is most effective for tumors 2 cm or smaller. The American College of Surgeons Oncology Group (ACOSOG) Z1072 trial reported a 100% success rate for tumors less than 1 cm and a 92% success rate for tumors up to 2 cm.
- Long-Term Success: A Japanese clinical trial involving 304 women with stage I invasive ductal carcinomas reported a 0.98% local recurrence rate over six years, demonstrating the long-term effectiveness of cryoablation when combined with anti-estrogen medications and radiation therapy.
- In April 2024, the 5-year follow-up results of the ICE3 trial were presented at the annual meeting of the American Society of Breast Surgeons in Orlando, Florida. The ICE3 trial is multicenter, single-arm, non-randomized clinical trial that evaluated the role of cryoablation as an alternative to surgery. The trial enrolled 194 women years of age (median 75 years) with unifocal, clinical stage I, histologic grade 1 or 2, estrogen receptor positive, progesterone receptor positive, HER2/neu negative invasive ductal carcinoma diagnosed by minimally invasive biopsy. The use of anti-estrogen therapy, radiation therapy, and sentinel node biopsy were not mandated by the trial. As such, nearly 80% of ICE3 trial participants utilized endocrine therapy but only 14% received adjuvant radiation therapy and only 8% of participants underwent a sentinel node biopsy. At 5 years of follow-up, there were 7 recurrences of cancer in the same breast yielding a local recurrence free survival rate of 96.7%, which is comparable to lumpectomy clinical trials in women over 60 years of age where radiation therapy was omitted. The 5-year results will be published soon.
Cryoablation also offers theoretical benefits in stimulating an anti-cancer immune response, although this effect is not yet fully proven in humans. Proteins released from cryoablated tumors may help the immune system recognize and attack remaining cancer cells, potentially providing additional protection against recurrence.
Quick, Minimally Invasive, and Highly Effective.
Effectiveness in killing targeted cancer cells.
Average duration of the cryoablation procedure.
Typical recovery time before resuming normal activites.
Local recurrence rate in patients over a 6-year folow-up.
Real Stories from Dr. Holmes’ Patients
I was truly blessed to have been recently operated by dr Holmes I am a physician myself and I saw the kindness commitment and care that he showed me that I shall try to emulate and follow The staff at Adventist the nurses and secretaries were all very kind and cooperative but ultimately it is the surgeon we remember I had no side effects after surgery and on the night after surgery I was able to share Chinese dinner with my husband and two sons I will refer anyone and everyone I know to choose him to be their surgeon May God bless him so he will continue to help others as he has helped me
Sheila D.
Patient
I have been reluctant to write a review on Dr. Dennis R. Holmes because I knew I would run out of adjectives. I was diagnosed with breast cancer at the beginning of November. I had gone for thermography at Safe Body Imaging and was lucky, so lucky, to meet Julie Steele. It was the results from that test that made me ask my internist for an ultrasound. I was floored by the results. Julie came to my rescue. She told me about Dr Holmes and cryoablation. Who ever heard of cryoablation? Even doctors don't know about this amazing technique. I called and spoke to Allison. Don't forget that name because she will be a big help if you decide to do the procedure. A conference call was set up between Dr Holmes, my daughter (an 8 year oncology nurse and now a Nurse Practitioner ) and myself. Dr Holmes has such a gentle nature, patience for a whole myriad of questions and he was able to calm my fears and hesitation. A few minutes after the call ended, my daughter called to say that, in her opinion., Dr Holmes was the best surgeon anyone could have and she totally supported.my decision. The following week I went to California. Even though I had complete trust and faith in Dr Holmes, I was still anxious.The morning of the procedure , I was put into position and promptly fell asleep. An hour later, I awoke and was shocked that everything was finished after Dr Holmes told me all that had transpired.. If I lived in California, I would have been sent home. Instead I was so hungry that I went to lunch, Since I live out of State, Dr Holmes wanted to see me the next day.. I can tell you that I had no side effects. No pain, no discomfort. It is not like surgery. No cutting, no scars etc. Everything looks the same. If you could feel your cancer before, you won't feel it now. You will bless this man for his talent, his humility and his humanity. There is no ego that gets in the way. This will be the best thing you will ever do for yourself with the best surgeon. Don't hesitate.
Barbara G.
Patient
I would like to thank Dr. Holmes for everything his done for me during the scariest time in my life. He is so knowledgeable, an excellent surgeon. He is kind, compassionate. Very patient taking his time to explain everything to me and my husband. He has a great team working with him. Alba was extremely helpful during this difficult time. I’m for ever grateful for everything you did for me during this very difficult time.
Lilly V.
Patient
Very thorough in detail, professional, excellent surgeon. And has a great team alongside him.
Alana O.
Patient
I am so glad that I spoke up for myself 2.5 years ago to request you as my breast surgeon. I can’t image what my experience would have been like if you weren’t part of my team. I was so fearful of this whole process. However, your knowledge, thoroughness, and compassion and the time you spent with me to work through the process was invaluable and put my mind at ease. Thanks for always answering all of my questions and addressing any concerns I may have. You are the best Dr. Holmes. Alba, thank you for always returning my phone calls and getting me in emergency or not. Both you and Dr. Holmes make on amazing team!
R. K.
Patient
Nice doctor, nice staff, Dr. Holmes spent a lot of time speaking with me regarding my upcoming procedure he wasn’t rushing with the appointment like a lot of doctors do he listened to my questions and concerns very happy with meeting with him
Toni M.
Patient
I wish I could give Dr. Holmes a 10 thousand-star rating! What a brilliant, compassionate physician he is! I flew to CA last year to be treated with cryoablation by Dr. Holmes. My trust and confidence in him are very well placed, and I am feeling great. He truly offers patient-centered care, which distinguishes him from so many other doctors. His assistant Allison is also exceptional in every regard...knowledgeable, responsive, thorough and kind. They gave me an alternative that changed my life, literally...and I am forever grateful! Thank you Dr. Holmes and Allison!
Donna B.
Patient
Dr. Dennis Holmes is an outstanding doctor. He is caring, personable and very easy to talk with. He is extremely knowledgeable and a leader in the field of breast cancer care. After being diagnosed with breast cancer I was told that the standard procedure with my type of cancer was a lumpectomy, radiation and possible chemotherapy with a hormone blocker which to me was devastating. I researched alternatives on my own and when I found Dr. Dennis Homes I was so grateful! He provided a cure for my cancer, cryoablation, that was much more endurable, minimally-invasive and cared about my emotional needs while managing my problem effectively. He gave me hope that I can get through this! His office staff is the best! Allison, who I interacted with a lot for appointments, questions to the doctor and whatever I needed always responded quickly, efficiently and with such kindness. I highly recommend Dr. Holmes and will be forever thankful for him and his staff!
Lorine C.
Patient
Very Caring physician made me feel SAFE
Clara C.
Patient
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