Effectiveness & Testimonials
Cryoablation has shown promising results in treating early-stage, hormone-sensitive breast cancers. The procedure involves using extreme cold to freeze and destroy cancerous tissues, offering a less invasive alternative to traditional surgeries like lumpectomy or mastectomy.
Cryoablation Improves Patient Satisfaction
Effective & Safe
Cancer control equal to lumpectomy for early stage breast cancer
Physical Well-being
Less pain or tightness and less difficulty with mobility, such as lifting arms.
Sexual Well-being
Greater feelings of sexual attractiveness, sexual confidence, and comfort level during sex
Satisfaction with Breasts
Greater happiness about breast size, how bras fit, and appearance in the mirror clothed or unclothed, as well as how the breasts feel to the touch.
Clinical Effectiveness of Cryoablation
Studies have highlighted the following key findings:
- Efficacy for Small Tumors: Cryoablation is most effective for tumors 2 cm or smaller. The American College of Surgeons Oncology Group (ACOSOG) Z1072 trial reported a 100% success rate for tumors less than 1 cm and a 92% success rate for tumors up to 2 cm.
- Long-Term Success: A Japanese clinical trial involving 304 women with stage I invasive ductal carcinomas reported a 0.98% local recurrence rate over six years, demonstrating the long-term effectiveness of cryoablation when combined with anti-estrogen medications and radiation therapy.
- In April 2024, the 5-year follow-up results of the ICE3 trial were presented at the annual meeting of the American Society of Breast Surgeons in Orlando, Florida. The ICE3 trial is multicenter, single-arm, non-randomized clinical trial that evaluated the role of cryoablation as an alternative to surgery. The trial enrolled 194 women years of age (median 75 years) with unifocal, clinical stage I, histologic grade 1 or 2, estrogen receptor positive, progesterone receptor positive, HER2/neu negative invasive ductal carcinoma diagnosed by minimally invasive biopsy. The use of anti-estrogen therapy, radiation therapy, and sentinel node biopsy were not mandated by the trial. As such, nearly 80% of ICE3 trial participants utilized endocrine therapy but only 14% received adjuvant radiation therapy and only 8% of participants underwent a sentinel node biopsy. At 5 years of follow-up, there were 7 recurrences of cancer in the same breast yielding a local recurrence free survival rate of 96.7%, which is comparable to lumpectomy clinical trials in women over 60 years of age where radiation therapy was omitted. The 5-year results will be published soon.
Cryoablation also offers theoretical benefits in stimulating an anti-cancer immune response, although this effect is not yet fully proven in humans. Proteins released from cryoablated tumors may help the immune system recognize and attack remaining cancer cells, potentially providing additional protection against recurrence.
Quick, Minimally Invasive, and Highly Effective.
Effectiveness in killing targeted cancer cells.
Average duration of the cryoablation procedure.
Typical recovery time before resuming normal activites.
Local recurrence rate in patients over a 6-year folow-up.
Real Stories from Dr. Holmes’ Patients
I am so glad that I spoke up for myself 2.5 years ago to request you as my breast surgeon. I can’t image what my experience would have been like if you weren’t part of my team. I was so fearful of this whole process. However, your knowledge, thoroughness, and compassion and the time you spent with me to work through the process was invaluable and put my mind at ease. Thanks for always answering all of my questions and addressing any concerns I may have. You are the best Dr. Holmes. Alba, thank you for always returning my phone calls and getting me in emergency or not. Both you and Dr. Holmes make on amazing team!
R K.
Patient
Well explained and take cared
Mary Ann F.
Patient
I wanted to express my appreciation to you for reviewing my medical file as a possible candidate for cryoablation. Even though I decided to have conventional surgery, the information that you, your staff and website provided was helpful for me to take a confident decision for my treatment. Allison from your staff was knowledgeable and very patient in answering my questions at a time that was emotional and filled with anxiety. Your staff evidently follows your lead in promoting a positive and kind atmosphere for your patients. Thank you for your time.
D C.
Patient
Dr. Dennis Holmes is an outstanding doctor. He is caring, personable and very easy to talk with. He is extremely knowledgeable and a leader in the field of breast cancer care. After being diagnosed with breast cancer I was told that the standard procedure with my type of cancer was a lumpectomy, radiation and possible chemotherapy with a hormone blocker which to me was devastating. I researched alternatives on my own and when I found Dr. Dennis Homes I was so grateful! He provided a cure for my cancer, cryoablation, that was much more endurable, minimally-invasive and cared about my emotional needs while managing my problem effectively. He gave me hope that I can get through this! His office staff is the best! Allison, who I interacted with a lot for appointments, questions to the doctor and whatever I needed always responded quickly, efficiently and with such kindness. I highly recommend Dr. Holmes and will be forever thankful for him and his staff!
Lorine C.
Patient
Excellent and he listens well and advices options.
Kimberly B.
Patient
Dr.Holmes is an amazing caring and knowledgeable person. I trusted him and now I am cancer free. Thank you Doc. God bless you
Asya A.
Patient
I personally have not had to be treated by Dr. Holmes, but I took my cousin for her treatments/surgery. Dr. Holmes is phenomenal! I have also recommended him to other women who are feeling so blessed to have him on their side during this tough time. Bless Dr. Holmes! Thank you.
Joan J.
Patient
Presented options I was not aware of and gave me hope
Pamela K.
Patient
My doctor referred me to doctor Holmes and it was the best thing for me. He is very detailed and explains every question I had, very nice , compassionate and knowledgeable. I know I am in good hands
Violeta G.
Patient
Submit Your Case
We invite you to submit your case for a free case preview with Dr. Dennis Holmes. Our goal is to make the process as easy and accessible as possible, ensuring you get the information and support you need.
